Fig. 1. TRPM2 expression is upregulated in lung tumor tissues and its downregulation in NSCLC cells reduces ADPR current. (A) microarray analysis of TRPM2 expression in normal and malignant lung tissues [24] (B & C) RT-qPCR and western blot analyses of TRPM2 expression level in scramble and TRPM2-KD NSCLC cells. (D & E) Whole-cell patch clamp analysis of TRPM2 channel activity in the presence of 2 mM ADPR (t test vs scr. ***, p<0.001; **, p<0.01; * p<0.05).